# Syllabus

## 20.106J/1.084J: Systems Microbiology

Microbiology from a systems perspective.

## Prerequisites

5.111, 5.112 or 3.091; 7.012, 7.013, or 7.014

## Course Textbook

Madigan, Michael, and John Martinko. *Brock Biology of Microorganisms*. 11th ed. Upper Saddle River, NJ: Pearson Prentice Hall, 2006. ISBN: 0131443291.

## Grading

ACTIVITIES | PERCENTAGE |
---|---|

Problem Sets (~1 every 2 weeks) | 25% |

Midterm I | 20% |

Midterm II | 20% |

Final Exam | 35% |

## Calendar

Lec # | TOPICS | LECTURERS | KEY DATES |
---|---|---|---|

1 | Early Earth/Microbial Evolution | Prof. Ed DeLong | |

2 | Cell Structure/Function | Prof. Ed DeLong | Problem set 1 out |

3 | Biological Energy Conservation | Prof. Ed DeLong | |

4 | Microbial Growth | Prof. David Schauer | Problem set 1 due |

5 | Metabolic Regulation | Prof. Ed DeLong | Problem set 2 out |

6 | Virology | Prof. David Schauer | |

7 | Information Flow in Biological Systems | Prof. Ed DeLong | Problem set 2 due |

Midterm I | |||

8 | Regulation of Cell Activity | Prof. Ed DeLong | Problem set 3 out |

9 | Genetic Exchange in Bacteria | Prof. Ed DeLong | |

10 | Experimental Evolution: Optimization of Metabolic Systems | Guest Lecturer, Prof. Christopher Marx from Harvard | Problem set 3 due |

11 | Genomics I | Prof. Ed DeLong | |

12 | Genomics II | Prof. Ed DeLong | Problem set 4 out |

13 | Metabolic Diversity I | Prof. Ed DeLong | |

14 | Metabolic Diversity II | Prof. Ed DeLong | |

15 | Microbial Ecology | Prof. Ed DeLong | Problem set 4 due |

Midterm II | |||

16 | Microbial Growth Control | Prof. David Schauer | Problem set 5 out |

17 | Microbe-host Interactions | Prof. David Schauer | |

18 | Immunology I | Megan McBee | |

19 | Immunology II | Megan McBee | Problem set 5 due |

20 | Diagnostic Microbiology | Prof. David Schauer | Problem set 6 out |

21 | Person-to-person Transmission | Prof. David Schauer | |

22 | Epidemiology | Megan McBee | Problem set 6 due |

23 | Animal- and Arthropod-transmitted Diseases | Prof. David Schauer | |

24 | Review | Prof. David Schauer | |

Final Exam |